Cyclopiazonic acid

Name: Cyclopiazonic acid
Brand: Tocris Bioscience
SKU: 1235
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1235

(2)

Citations (127)

COA / SDS

Inhibitor of SERCA ATPase

Key Product Details

Description:	Inhibitor of SERCA ATPase
Alternative Names:	α-Cyclopiazonic acid
Chemical Name:	(6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
Purity:	≥98% (HPLC)
Molecular Weight:	336.39

View Full Technical Details for Cyclopiazonic acid

Technical Data
Citations / Reviews (2)

Biological Activity for Cyclopiazonic acid

Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca²⁺-ATPase.

Technical Data for Cyclopiazonic acid

M. Wt	336.39
Formula	C₂₀H₂₀N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	18172-33-3
PubChem ID	54682463
InChi Key	SZINUGQCTHLQAZ-DQYPLSBCSA-N
Smiles	OC([C@](N4C(C)5C)([H])[C@]1([H])[C@@]5([H])CC3=C2C1=CNC2=CC=C3)=C(C(C)=O)C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclopiazonic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.64	100

Preparing Stock Solutions for Cyclopiazonic acid

The following data is based on the product molecular weight 336.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.73 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for Cyclopiazonic acid

References are publications that support the biological activity of the product.

Soler Cyclopiazonic acid effect on Ca²⁺-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry 1998 PMID: 9521749
Takemoto Comparison of contractions produced by CB, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle. Br.J.Pharmacol. 1998 PMID: 9723957
Plenge-Tellechea On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca²⁺-ATPases by cyclopiazonic acid. J.Biol.Chem. 1997 PMID: 9006919