Cyclosomatostatin

Name: Cyclosomatostatin
Brand: Tocris Bioscience
SKU: 3493

Tocris Bioscience, part of Bio-Techne | Catalog # 3493

Citations (16)

COA / SDS

Non-selective sst antagonist

Key Product Details

Description:	Non-selective sst antagonist
Alternative Names:	Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])
Purity:	≥95% (HPLC)
Molecular Weight:	779.98

View Full Technical Details for Cyclosomatostatin

Technical Data
Citations

Biological Activity for Cyclosomatostatin

Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

Technical Data for Cyclosomatostatin

M. Wt	779.98
Formula	C₄₄H₅₇N₇O₆
Single Letter Sequence	FWKT (Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-2 = D-Trp, Thr-4 = Bn-Thr), lactam bridge: Phe-1 to Thr-4
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	84211-54-1
PubChem ID	122080
InChi Key	YHVHQZYJGWGAKN-ZUWUZHNASA-N
Smiles	C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cyclosomatostatin

Solubility

Soluble to 1mg/ml in 20% ethanol / water

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References for Cyclosomatostatin

References are publications that support the biological activity of the product.

Stirnweis The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 2002 PMID: 12182954
Guo Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 2008 PMID: 18640104
Fries Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat. Peptides 1982 PMID: 6129618