CYM 50308

Name: CYM 50308
Brand: Tocris Bioscience
SKU: 4678

Tocris Bioscience, part of Bio-Techne | Catalog # 4678

Citations (4)

COA / SDS

Potent and selective S1P4 agonist

Key Product Details

Description:	Potent and selective S1P₄ agonist
Chemical Name:	(2Z,5Z)-5-[[1-(2,4-Difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone
Purity:	≥98% (HPLC)
Molecular Weight:	405.46

View Full Technical Details for CYM 50308

Technical Data
Citations

Biological Activity for CYM 50308

CYM 50308 is a potent and selective sphingosine-1-phosphate receptor 4 (S1P₄) agonist (EC₅₀ values are 56 nM and 2100 nM for S1P₄ and S1P₅ receptors, respectively). Displays no activity at S1P₁, S1P₂ and S1P₃ receptors at concentrations up to 25 μM.

Technical Data for CYM 50308

M. Wt	405.46
Formula	C₂₀H₂₁F₂N₃O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1345858-76-5
PubChem ID	49835928
InChi Key	BKQZKTRCUAWRHT-ONBPWHQPSA-N
Smiles	FC1=CC(F)=C(N2C(C)=CC(/C=C3\S/C(N(C)C3=O)=N\CCOC)=C2C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CYM 50308

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.05	10

Preparing Stock Solutions for CYM 50308

The following data is based on the product molecular weight 405.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.66 mL	123.32 mL	246.63 mL
0.5 mM	4.93 mL	24.66 mL	49.33 mL
1 mM	2.47 mL	12.33 mL	24.66 mL
5 mM	0.49 mL	2.47 mL	4.93 mL

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References for CYM 50308

References are publications that support the biological activity of the product.

Urbano Discovery, synthesis and SAR analysis of novel selective small molecule S1P₄-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg.Med.Chem.Lett. 2011 PMID: 21982495