CYM 50358 hydrochloride

Name: CYM 50358 hydrochloride
Brand: Tocris Bioscience
SKU: 4679

Tocris Bioscience, part of Bio-Techne | Catalog # 4679

Citations (6)

COA / SDS

Potent and selective S1P4 antagonist

Key Product Details

Description:	Potent and selective S1P₄ antagonist
Chemical Name:	N-[(4-(Aminomethyl)-2,6-dimethylphenyl]-5-(2,5-dichlorophenyl)-2-furancarboxamide hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	425.74

View Full Technical Details for CYM 50358 hydrochloride

Technical Data
Citations

Biological Activity for CYM 50358 hydrochloride

CYM 50358 hydrochloride is a potent S1P₄ antagonist (IC₅₀ = 25 nM). Displays selectivity for S1P₄ against S1P₁, S1P₂, S1P₃ and S1P₅ receptors.

Technical Data for CYM 50358 hydrochloride

M. Wt	425.74
Formula	C₂₀H₁₈Cl₂N₂O₂.HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1781750-72-8
PubChem ID	78243726
InChi Key	OFDSTJOMVDAKCS-UHFFFAOYSA-N
Smiles	O=C(NC3=C(C)C=C(CN)C=C3C)C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CYM 50358 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	42.57	100
	DMSO	42.57	100

Preparing Stock Solutions for CYM 50358 hydrochloride

The following data is based on the product molecular weight 425.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.35 mL	11.74 mL	23.49 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
10 mM	0.23 mL	1.17 mL	2.35 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for CYM 50358 hydrochloride

References are publications that support the biological activity of the product.

Cencetti TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB J. 2013 PMID: 23913862
Guerrero Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P₄) receptor antagonists. Bioorg.Med.Chem.Lett. 2011 PMID: 21570287