D-Serine

Name: D-Serine
Brand: Tocris Bioscience
SKU: 0226

Tocris Bioscience, part of Bio-Techne | Catalog # 0226

Citations (55)

COA / SDS

Potentiator of NMDA recepors; acts at glycine site

Key Product Details

Description:	Potentiator of NMDA recepors; acts at glycine site
Molecular Weight:	105.09

View Full Technical Details for D-Serine

Technical Data
Citations

Biological Activity for D-Serine

D-Serine is a glycine agonist at the NMDA receptor.

Technical Data for D-Serine

M. Wt	105.09
Formula	C₃H₇NO₃
Storage	Store at RT
CAS Number	312-84-5
PubChem ID	71077
InChi Key	MTCFGRXMJLQNBG-UWTATZPHSA-N
Smiles	N[C@@]([H])([C@](O)=O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D-Serine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for D-Serine

The following data is based on the product molecular weight 105.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.52 mL	47.58 mL	95.16 mL
5 mM	1.90 mL	9.52 mL	19.03 mL
10 mM	0.95 mL	4.76 mL	9.52 mL
50 mM	0.19 mL	0.95 mL	1.90 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for D-Serine

References are publications that support the biological activity of the product.

Lodge Non-competitive NMDA antagonists. The NMDA Receptor (2nd edition). Eds. G.L.Collingr
Mothet D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc.Natl.Acad.Sci.USA 2000 PMID: 10781100
Schell D-Serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci. 1997 PMID: 9030620