D609

Name: D609
Brand: Tocris Bioscience
SKU: 1437
Rating: 4 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1437

(2)

Citations (29)

COA / SDS

Selective PC-PLC inhibitor

Key Product Details

Description:	Selective PC-PLC inhibitor
Chemical Name:	O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate
Purity:	≥98% (HPLC)
Molecular Weight:	266.46

View Full Technical Details for D609

Technical Data
Citations / Reviews (2)

Biological Activity for D609

D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (K_i = 6.4 μM); antiviral and antitumor agent. Also inhibits sphingomyelin synthase. Suppresses LPS- and IFNγ-induced NO production (IC₅₀ = 20 mg/ml) and blocks oxidative glutamate toxicity in nerve cells. Antioxidant in vivo.

Technical Data for D609

M. Wt	266.46
Formula	C₁₁H₁₅OS₂K
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	83373-60-8
PubChem ID	4234241
InChi Key	IGULCCCBGBDZKQ-UHFFFAOYSA-M
Smiles	S=C(S[K])OC1CC2C3CCCC3C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for D609

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.65	100

Preparing Stock Solutions for D609

The following data is based on the product molecular weight 266.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.76 mL	37.53 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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Reconstitution Calculator

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References for D609

References are publications that support the biological activity of the product.

Adibhatla Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem.Res. 2012 PMID: 22101393
Tschiakowsky Induction of nitric oxide synthase activity in phagocytic cells inhibited by tricyclodecan-9-yl-xanthogenate (D609). Br.J.Pharmacol. 1994 PMID: 7532078
Zhou D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J.Pharmacol.Exp.Ther. 2001 PMID: 11408530
Amtmann The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp.Clin.Res. 1996 PMID: 9034754