DDR1-IN-1 dihydrochloride

Name: DDR1-IN-1 dihydrochloride
Brand: Tocris Bioscience
SKU: 5077

Tocris Bioscience, part of Bio-Techne | Catalog # 5077

(1)

Citations (10)

COA / SDS

Selective DDR1 inhibitor

Key Product Details

Chemical Name:	N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Purity:	≥98%

View Full Technical Details for DDR1-IN-1 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC₅₀ values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

Technical Data for DDR1-IN-1 dihydrochloride

Formula	C₃₀H₃₁F₃N₄O₃.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	1780303-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DDR1-IN-1 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 50 mM in DMSO

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References for DDR1-IN-1 dihydrochloride

References are publications that support the biological activity of the product.

V Abbonante, CA Di Buduo, C Gruppi, C De Maria, E Spedden, A De Acutis, C Staii, M Raspanti, G Vozzi, D Kaplan, F Moccia, K Ravid, A Balduini A new path to platelet production through matrix sensing Haematologica, 2017;0(0):. 2017 PMID: 28411253
Kim et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol., 2013;8:2145 PMID: 23899692
Canning et al. Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol., 2014;426:2457 PMID: 24768818

DDR1-IN-1 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5077

Key Product Details

Biological Activity for DDR1-IN-1 dihydrochloride

Technical Data for DDR1-IN-1 dihydrochloride

Solubility for DDR1-IN-1 dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for DDR1-IN-1 dihydrochloride

Product Documents for DDR1-IN-1 dihydrochloride

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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