Decitabine

Name: Decitabine
Brand: Tocris Bioscience
SKU: 2624

Tocris Bioscience, part of Bio-Techne | Catalog # 2624

(1)

Citations (27)

COA / SDS

DNA methyltransferase inhibitor

Key Product Details

Chemical Name:	4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Purity:	≥99%

View Full Technical Details for Decitabine

Technical Data
Citations / Reviews (1)

Biological Activity for Decitabine

Decitabine is a cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

For more information about how Decitabine may be used, see our protocol:

Highly Efficient Generation of CiPSCs from MEFs

Technical Data for Decitabine

Formula	C₈H₁₂N₄O₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	2353-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Decitabine

Solubility

Soluble Soluble to 50 mM in water and to 50 mM in DMSO

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References for Decitabine

References are publications that support the biological activity of the product.

Park H, Choi Y, Kim J, Chun H, Im I, Yoon S, Han Y, Song C, Kim H Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes. PLoS ONE, 2015;10(7):e0132992. 2015 PMID: 26177506
Bender et al. Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res., 1998;58:95 PMID: 9426064
Momparler Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol., 2005;42:S9 PMID: 16015507
Jackson-Grusby et al. Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc.Natl.Acad.Sci.USA, 1997;94:4681

Decitabine

Tocris Bioscience, part of Bio-Techne | Catalog # 2624

Key Product Details

Biological Activity for Decitabine

Technical Data for Decitabine

Solubility for Decitabine

Dilution Calculator

Reconstitution Calculator

References for Decitabine

Product Documents for Decitabine

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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