Deferoxamine mesylate

Name: Deferoxamine mesylate
Brand: Tocris Bioscience
SKU: 5764

Tocris Bioscience, part of Bio-Techne | Catalog # 5764

Citations (1)

COA / SDS

Iron chelator; also hypoxia mimetic and neuroprotectant

Key Product Details

Description:	Iron chelator; also hypoxia mimetic and neuroprotectant
Chemical Name:	N⁴-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N¹-(5-aminopentyl)-N¹-hydroxybutanediamide methanesulfonate
Molecular Weight:	656.79

View Full Technical Details for Deferoxamine mesylate

Technical Data
Citations

Biological Activity for Deferoxamine mesylate

Deferoxamine mesylate is an iron chelator. Also hypoxia mimetic and inhibitor of ferroptosis. Has neuroprotective effects in animal models of stroke, traumatic brain injury and neurodegenerative diseases.

Technical Data for Deferoxamine mesylate

M. Wt	656.79
Formula	C₂₅H₄₈N₆O₈.CH₄O₃S
Storage	Store at -20°C
CAS Number	138-14-7
PubChem ID	62881
InChi Key	IDDIJAWJANBQLJ-UHFFFAOYSA-N
Smiles	ON(C(CCC(NCCCCCN(C(CCC(NCCCCCN(O)C(C)=O)=O)=O)O)=O)=O)CCCCCN.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Deferoxamine mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	65.68	100

Preparing Stock Solutions for Deferoxamine mesylate

The following data is based on the product molecular weight 656.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.61 mL	15.23 mL
5 mM	0.30 mL	1.52 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

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References for Deferoxamine mesylate

References are publications that support the biological activity of the product.

Kosyakovsky Quantifying intranasally administered deferoxamine in rat brain tissue with mass spectrometry. ACS Chem.Neurosci. 2019 PMID: 31573798
Chau Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors. Cancer Res. 2005 PMID: 15930314