DEL 22379

Name: DEL 22379
Brand: Tocris Bioscience
SKU: 5774

Tocris Bioscience, part of Bio-Techne | Catalog # 5774

Citations (2)

COA / SDS

ERK dimerization inhibitor

Key Product Details

Description:	ERK dimerization inhibitor
Chemical Name:	N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
Purity:	≥98% (HPLC)
Molecular Weight:	444.53

View Full Technical Details for DEL 22379

Technical Data
Citations

Biological Activity for DEL 22379

DEL 22379 is an ERK dimerization inhibitor (IC₅₀ ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.

Technical Data for DEL 22379

M. Wt	444.53
Formula	C₂₆H₂₈N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	181223-80-3
PubChem ID	11224574
InChi Key	INQUULPXCZAKMS-XKZIYDEJSA-N
Smiles	O=C1NC2=CC=C(NC(CCN3CCCCC3)=O)C=C2/C1=C/C4=CNC5=C4C=C(OC)C=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DEL 22379

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.23	50

Preparing Stock Solutions for DEL 22379

The following data is based on the product molecular weight 444.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.50 mL	22.50 mL	44.99 mL
2.5 mM	0.90 mL	4.50 mL	9.00 mL
5 mM	0.45 mL	2.25 mL	4.50 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for DEL 22379

References are publications that support the biological activity of the product.

Ryan Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 2015 PMID: 26858988
Herrero Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 2015 PMID: 26267534