Desmopressin

Name: Desmopressin
Brand: Tocris Bioscience
SKU: 3396

Tocris Bioscience, part of Bio-Techne | Catalog # 3396

Citations (7)

COA / SDS

Synthetic vasopressin analog; V1B and V2 agonist

Key Product Details

Description:	Synthetic vasopressin analog; V_1B and V₂ agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1069.22

View Full Technical Details for Desmopressin

Technical Data
Citations

Biological Activity for Desmopressin

Desmopressin is a synthetic vasopressin analog that acts as an agonist at V_1B and V₂ receptors (EC₅₀ values are 11.4 and 23.9 nM and K_i values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.

Technical Data for Desmopressin

M. Wt	1069.22
Formula	C₄₆H₆₄N₁₄O₁₂S₂
Single Letter Sequence	XYFQNCPRG (Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	16679-58-6
PubChem ID	5311065
InChi Key	NFLWUMRGJYTJIN-PNIOQBSNSA-N
Smiles	NC(=O)CC[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Desmopressin

Solubility

Soluble to 4mg/ml in water

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References for Desmopressin

References are publications that support the biological activity of the product.

Gomez Desmopressin and other synthetic vasopressin analogues in cancer treatment. Bull.Cancer 2006 PMID: 16517412
Torres Vasopressin antagonists in polycystic kidney disease. Semin.Nephrol. 2008 PMID: 18519091
Saito 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V_1b vasopressin receptor. Biochem.Pharmacol. 1997 PMID: 9264324