DG 172 dihydrochloride

Name: DG 172 dihydrochloride
Brand: Tocris Bioscience
SKU: 5566

Tocris Bioscience, part of Bio-Techne | Catalog # 5566

COA / SDS

Potent PPARβ/δ inverse agonist; promotes BMC differentiation

Discontinued Product

5566 has been discontinued. View all Additional Non-selective PPAR Receptor Compounds products.

Key Product Details

Description:	Potent PPARβ/δ inverse agonist; promotes BMC differentiation
Chemical Name:	(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	455.22

View Full Technical Details for DG 172 dihydrochloride

Technical Data
Citations

Biological Activity for DG 172 dihydrochloride

DG 172 dihydrochloride is a potent PPARβ/δ inverse agonist (IC₅₀ = 26.9 nM). Inhibits Angptl4 gene expression in mouse myoblasts (IC₅₀ = 9.5 nM) in vitro. Also augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture. Orally available.

Technical Data for DG 172 dihydrochloride

M. Wt	455.22
Formula	C₂₀H₂₀BrN₃.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1361504-77-9
PubChem ID	57342888
InChi Key	SABUORLIDVBCPI-WTLOABTRSA-N
Smiles	BrC(C=CC=C1)=C1/C(C#N)=C/C2=CC=C(N3CCN(C)CC3)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DG 172 dihydrochloride

References are publications that support the biological activity of the product.

Lieber (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J.Med.Chem. 2012 PMID: 22369181
Lieber The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Mol.Pharmacol. 2015 PMID: 25398837

DG 172 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5566

Key Product Details

Biological Activity for DG 172 dihydrochloride

Technical Data for DG 172 dihydrochloride

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DG 172 dihydrochloride

Product Documents for DG 172 dihydrochloride

COA

Certificate of Analysis

SDS

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