DHC-156

Name: DHC-156
Brand: Tocris Bioscience
SKU: 8168

Tocris Bioscience, part of Bio-Techne | Catalog # 8168

COA / SDS

Brachyury down modulator

Key Product Details

Description:	Brachyury down modulator
Chemical Name:	(E)-4-(Dimethylamino)-N-[1-[4-fluoro-3-(2,2,2-trifluoroethoxy)anilino]-6-methoxy-7-isoquinolyl]but-2-enamide
Purity:	≥98% (HPLC)
Molecular Weight:	492.47

View Full Technical Details for DHC-156

Technical Data
Citations

Biological Activity for DHC-156

DHC-156 is a brachyury down modulator (DC₅₀ = 4.1 μM, D_Max > 99% at 10 μM). DHC-156 down modulates brachyury post-translationally, in a proteasome- and lysosome-independent manner. DHC-156 down modulation of brachyury results in an irreversible impairment of chordoma tumor cell growth.

Technical Data for DHC-156

M. Wt	492.47
Formula	C₂₄H₂₄F₄N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	171038043
InChi Key	SBZOWNJIUPEINK-SNAWJCMRSA-N
Smiles	COC1=C(C=C2C(NC3=CC(OCC(F)(F)F)=C(C=C3)F)=NC=CC2=C1)NC(/C=C/CN(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DHC-156

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.25	100

Preparing Stock Solutions for DHC-156

The following data is based on the product molecular weight 492.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.15 mL	20.31 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for DHC-156

References are publications that support the biological activity of the product.

Chase Development of a small molecule downmodulator for the transcription factor brachyury. Angew.Chem.Int.Ed.Engl. 2024 PMID: 38348945