Digoxin

Name: Digoxin
Brand: Tocris Bioscience
SKU: 4583

Tocris Bioscience, part of Bio-Techne | Catalog # 4583

Citations (22)

COA / SDS

Na+/K+ ATPase inhibitor

Key Product Details

Description:	Na⁺/K⁺ ATPase inhibitor
Chemical Name:	4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	780.94

View Full Technical Details for Digoxin

Technical Data
Citations

Biological Activity for Digoxin

Digoxin is an inhibits membrane-bound α-subunits of the Na⁺/K⁺ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na⁺/K⁺ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.17 μM).

Technical Data for Digoxin

M. Wt	780.94
Formula	C₄₁H₆₄O₁₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	20830-75-5
PubChem ID	12940973
InChi Key	LTMHDMANZUZIPE-PUGKRICDSA-N
Smiles	O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@]4(C[C@H]([C@@]32C)O)[H])C)O[C@@]6(O[C@@H]([C@H]([C@H](C6)O)O[C@]7(C[C@@H]([C@@H]([C@H](O7)C)O[C@@]8(O[C@@H]([C@H]([C@H](C8)O)O)C)[H])O)[H])C)[H])[H])=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Digoxin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	78.09	100

Preparing Stock Solutions for Digoxin

The following data is based on the product molecular weight 780.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.28 mL	6.40 mL	12.81 mL
5 mM	0.26 mL	1.28 mL	2.56 mL
10 mM	0.13 mL	0.64 mL	1.28 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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References for Digoxin

References are publications that support the biological activity of the product.

Ko Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 2021 PMID: 33918958
Gheorghiade Digoxin in the management of cardiovascular disorders. Circulation 2004 PMID: 15210613
Sjogren Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels. Mol.Pharmacol. 2012 PMID: 22695717
Buckalew Endogenous digitalis-like factors. An historical overview. Front.Biosci. 2005 PMID: 15970498