Dihydrexidine hydrochloride

Name: Dihydrexidine hydrochloride
Brand: Tocris Bioscience
SKU: 0884
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0884

Citations (10)

COA / SDS

Selective D1-like agonist

Key Product Details

Description:	Selective D₁-like agonist
Chemical Name:	(±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	303.79

View Full Technical Details for Dihydrexidine hydrochloride

Technical Data
Citations

Biological Activity for Dihydrexidine hydrochloride

Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D₁ agonist which shows no agonist activity at peripheral D₂ receptors or adrenoceptors at doses which cause maximal stimulation of D₁ sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.

Licensing Information

Sold under license, US Patent 5,047,536

Technical Data for Dihydrexidine hydrochloride

M. Wt	303.79
Formula	C₁₇H₁₇NO₂.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	137417-08-4
PubChem ID	11403931
InChi Key	IJYUPBNUPIRQEP-SATBOSKTSA-N
Smiles	OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dihydrexidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.04	10
	DMSO	15.19	50

Preparing Stock Solutions for Dihydrexidine hydrochloride

The following data is based on the product molecular weight 303.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.58 mL	32.92 mL	65.83 mL
2.5 mM	1.32 mL	6.58 mL	13.17 mL
5 mM	0.66 mL	3.29 mL	6.58 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

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Reconstitution Calculator

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References for Dihydrexidine hydrochloride

References are publications that support the biological activity of the product.

Taylor Dihydrexidine, a full DA D₁ agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 1991 PMID: 1680717
Kholi Dihydrexidine: a new potent peripheral DA D₁ receptor agonist. Eur.J.Pharmacol. 1993 PMID: 8100195
Lovenberg Dihydrexidine, a novel selective high potency, full DA D-1 receptor agonist. Eur.J.Pharmacol. 1989 PMID: 2572425
Brewster Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective DA D₁ full agonist. J.Med.Chem. 1990 PMID: 1971308