Diltiazem hydrochloride

Name: Diltiazem hydrochloride
Brand: Tocris Bioscience
SKU: 0685

Tocris Bioscience, part of Bio-Techne | Catalog # 0685

Citations (19)

COA / SDS

CaV1.x blocker

Key Product Details

Description:	Ca_V1.x blocker
Chemical Name:	(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	450.98

View Full Technical Details for Diltiazem hydrochloride

Technical Data
Citations

Biological Activity for Diltiazem hydrochloride

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent; an inhibitor of L-type Ca²⁺ channels.

Compound Libraries for Diltiazem hydrochloride

Diltiazem hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Diltiazem hydrochloride

M. Wt	450.98
Formula	C₂₂H₂₆N₂O₄S.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	33286-22-5
PubChem ID	62920
InChi Key	HDRXZJPWHTXQRI-BHDTVMLSSA-N
Smiles	[H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Diltiazem hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		100
	DMSO	45.1	100

Preparing Stock Solutions for Diltiazem hydrochloride

The following data is based on the product molecular weight 450.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.09 mL	22.17 mL
5 mM	0.44 mL	2.22 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for Diltiazem hydrochloride

References are publications that support the biological activity of the product.

Kraus Molecular mechanisms of dilt. interaction with L-type Ca²⁺ channels. J.Biol.Chem. 1998 PMID: 9765241
Gandia Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 1996 PMID: 8818357
Ishibashi Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 1995 PMID: 8574653
Dagani Effects of dilt. on bioenergetics, K⁺ gradients, and free cytosolic Ca²⁺ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 1989 PMID: 2795006

Product Documents for Diltiazem hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Diltiazem hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov