Diphenhydramine hydrochloride

Name: Diphenhydramine hydrochloride
Brand: Tocris Bioscience
SKU: 3072

Tocris Bioscience, part of Bio-Techne | Catalog # 3072

Citations (2)

COA / SDS

H1 antagonist

Key Product Details

Description:	H₁ antagonist
Alternative Names:	DPH
Chemical Name:	2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	291.82

View Full Technical Details for Diphenhydramine hydrochloride

Technical Data
Citations

Biological Activity for Diphenhydramine hydrochloride

Diphenhydramine hydrochloride is a H₁ receptor antagonist. Antihistamine.

Technical Data for Diphenhydramine hydrochloride

M. Wt	291.82
Formula	C₁₇H₂₁NO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	147-24-0
PubChem ID	8980
InChi Key	PCHPORCSPXIHLZ-UHFFFAOYSA-N
Smiles	CN(CCOC(C2=CC=CC=C2)C1=CC=CC=C1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Diphenhydramine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	29.18	100

Preparing Stock Solutions for Diphenhydramine hydrochloride

The following data is based on the product molecular weight 291.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.13 mL	34.27 mL
5 mM	0.69 mL	3.43 mL	6.85 mL
10 mM	0.34 mL	1.71 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Diphenhydramine hydrochloride

References are publications that support the biological activity of the product.

Khalia Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramide. J.Pharmacol.Exp.Ther. 1999 PMID: 9918600