DMPQ dihydrochloride

Name: DMPQ dihydrochloride
Brand: Tocris Bioscience
SKU: 1222

Tocris Bioscience, part of Bio-Techne | Catalog # 1222

COA / SDS

Potent, selective inhibitor of PDGFRβ

Key Product Details

Description:	Potent, selective inhibitor of PDGFRβ
Chemical Name:	5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	339.22

View Full Technical Details for DMPQ dihydrochloride

Technical Data
Citations

Biological Activity for DMPQ dihydrochloride

DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC₅₀ = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

Technical Data for DMPQ dihydrochloride

M. Wt	339.22
Formula	C₁₆H₁₄N₂O₂.2HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1123491-15-5
PubChem ID	45073427
InChi Key	YBBAOKYVJCNJIV-UHFFFAOYSA-N
Smiles	COC1=CC(OC)=C2C(N=CC(C3=CC=NC=C3)=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DMPQ dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions for DMPQ dihydrochloride

The following data is based on the product molecular weight 339.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.74 mL	29.48 mL
5 mM	0.59 mL	2.95 mL	5.90 mL
10 mM	0.29 mL	1.47 mL	2.95 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Reconstitution Calculator

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References for DMPQ dihydrochloride

References are publications that support the biological activity of the product.

Dolle 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 1994 PMID: 8064792