Docetaxel

Name: Docetaxel
Brand: Tocris Bioscience
SKU: 4056
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4056

(1)

Citations (27)

COA / SDS

Microtubule stabilizer

Key Product Details

Description:	Microtubule stabilizer
Chemical Name:	[2aR-[2aα,4β,4aβ,6β,9α(αR,βS),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	807.88

View Full Technical Details for Docetaxel

Technical Data
Citations / Reviews (1)

Biological Activity for Docetaxel

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Compound Libraries for Docetaxel

Docetaxel is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Docetaxel

M. Wt	807.88
Formula	C₄₃H₅₃NO₁₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	114977-28-5
PubChem ID	148124
InChi Key	ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Smiles	O[C@@H]1C4=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C[C@@](C(C)4C)(O)[C@@H](OC(C6=CC=CC=C6)=O)[C@@]([C@@]3(OC(C)=O)[C@H](OC3)C[C@@H]2O)([H])[C@]2(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Docetaxel

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	80.79	100
	ethanol	80.79	100

Preparing Stock Solutions for Docetaxel

The following data is based on the product molecular weight 807.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.24 mL	6.19 mL	12.38 mL
5 mM	0.25 mL	1.24 mL	2.48 mL
10 mM	0.12 mL	0.62 mL	1.24 mL
50 mM	0.02 mL	0.12 mL	0.25 mL

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References for Docetaxel

References are publications that support the biological activity of the product.

Ramaswamy and Puhalla Docetaxel: a tubulin-stabilizing agent approved for the management of several solid tumors. Drugs Today (Barc) 2006 PMID: 16703123
Lyseng-Williamson and Fenton Docetaxel: a review of its use in metastatic breast cancer. Drugs 2005 PMID: 16296875