Docosahexaenoic acid

Name: Docosahexaenoic acid
Brand: Tocris Bioscience
SKU: 3687
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3687

(1)

Citations (4)

COA / SDS

RXR agonist

Key Product Details

Description:	RXR agonist
Alternative Names:	DHA
Chemical Name:	(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
Purity:	≥98%
Molecular Weight:	328.49

View Full Technical Details for Docosahexaenoic acid

Technical Data
Citations / Reviews (1)

Biological Activity for Docosahexaenoic acid

Docosahexaenoic acid is a endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

Technical Data for Docosahexaenoic acid

M. Wt	328.49
Formula	C₂₂H₃₂O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	6217-54-5
PubChem ID	445580
InChi Key	MBMBGCFOFBJSGT-KUBAVDMBSA-N
Smiles	CC\C=C/C\C=C/C\C=C/C/C=C\C/C=C\C/C=C\CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Docosahexaenoic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.85	100
	ethanol	32.85	100

Preparing Stock Solutions for Docosahexaenoic acid

The following data is based on the product molecular weight 328.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.22 mL	30.44 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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Reconstitution Calculator

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References for Docosahexaenoic acid

References are publications that support the biological activity of the product.

Zapata-Gonzalez Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 2008 PMID: 18632990
Hossain Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ_1-42 fibrillation and Aβ_1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 2009 PMID: 19686246
Mata de Urqunia Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 2000 PMID: 11118147