DPN

Name: DPN
Brand: Tocris Bioscience
SKU: 1494

Tocris Bioscience, part of Bio-Techne | Catalog # 1494

Citations (166)

COA / SDS

Highly potent ERβ agonist

Key Product Details

Description:	Highly potent ERβ agonist
Alternative Names:	Diarylpropionitrile
Chemical Name:	2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity:	≥99% (HPLC)
Molecular Weight:	239.27

View Full Technical Details for DPN

Technical Data
Citations

Biological Activity for DPN

DPN is a highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC₅₀ values are 0.85 and 66 nM respectively). Relaxes mesenteric arteries in vitro. Shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus.

Technical Data for DPN

M. Wt	239.27
Formula	C₁₅H₁₃NO₂
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	1428-67-7
PubChem ID	102614
InChi Key	GHZHWDWADLAOIQ-UHFFFAOYSA-N
Smiles	OC1=CC=C(CC(C#N)C2=CC=C(O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DPN

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	7.18	30
	ethanol	23.93	100
	DMSO	23.93	100

Preparing Stock Solutions for DPN

The following data is based on the product molecular weight 239.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.18 mL	20.90 mL	41.79 mL
5 mM	0.84 mL	4.18 mL	8.36 mL
10 mM	0.42 mL	2.09 mL	4.18 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for DPN

References are publications that support the biological activity of the product.

Waters Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus. Brain Res. 2009 PMID: 19596275
Meyers Estrogen receptor-β potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J.Med.Chem. 2001 PMID: 11708925
Montgomery Acute effects of oestrogen receptor subtype-specific agonists on vascular contractility. Br.J.Pharmacol. 2003 PMID: 12890703
Harrington Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 2003 PMID: 12943986

DPN