DPPI 1c hydrochloride

Name: DPPI 1c hydrochloride
Brand: Tocris Bioscience
SKU: 2783

Tocris Bioscience, part of Bio-Techne | Catalog # 2783

Citations (2)

COA / SDS

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Key Product Details

Description:	Dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name:	1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	312.8

View Full Technical Details for DPPI 1c hydrochloride

Technical Data
Citations

Biological Activity for DPPI 1c hydrochloride

DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC₅₀ = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC₅₀ > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

Compound Libraries for DPPI 1c hydrochloride

DPPI 1c hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DPPI 1c hydrochloride

M. Wt	312.8
Formula	C₁₄H₂₀N₄O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	866396-70-5
PubChem ID	11381415
InChi Key	RHCWAHDCHQTNBR-IWKKHLOMSA-N
Smiles	O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DPPI 1c hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.28	100
	water	15.64	50

Preparing Stock Solutions for DPPI 1c hydrochloride

The following data is based on the product molecular weight 312.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	15.98 mL	31.97 mL
5 mM	0.64 mL	3.20 mL	6.39 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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Reconstitution Calculator

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References for DPPI 1c hydrochloride

References are publications that support the biological activity of the product.

Wright cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 2006 PMID: 16722626