Dynamin inhibitory peptide

Name: Dynamin inhibitory peptide
Brand: Tocris Bioscience
SKU: 1774

Tocris Bioscience, part of Bio-Techne | Catalog # 1774

COA / SDS

Dynamin inhibitor

Discontinued Product

1774 has been discontinued. View all Dynamin Inhibitors products.

Key Product Details

Description:	Dynamin inhibitor
Alternative Names:	P4
Purity:	≥95% (HPLC)
Molecular Weight:	1121.26

View Full Technical Details for Dynamin inhibitory peptide

Technical Data
Citations

Biological Activity for Dynamin inhibitory peptide

Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABA_A receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABA_A receptors.

Cell-permeable version also available.

Technical Data for Dynamin inhibitory peptide

M. Wt	1121.26
Formula	C₄₇H₈₀N₁₈O₁₄
Single Letter Sequence	QVPSRPNRAP
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	251634-21-6
PubChem ID	90488708
InChi Key	LHQOQXYEPUSHJL-LNIRUYPRSA-N
Smiles	[H]N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Dynamin inhibitory peptide

References are publications that support the biological activity of the product.

Kittler Constitutive endocytosis of GABA_A receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 2000 PMID: 11050117
Nong Glycine binding primes NMDA receptor internalization. Nature 2003 PMID: 12646920
Grabs The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 1997 PMID: 9148966

Dynamin inhibitory peptide

Tocris Bioscience, part of Bio-Techne | Catalog # 1774

Key Product Details

Biological Activity for Dynamin inhibitory peptide

Technical Data for Dynamin inhibitory peptide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Dynamin inhibitory peptide

Product Documents for Dynamin inhibitory peptide

COA

Certificate of Analysis

SDS

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