Dynarrestin

Name: Dynarrestin
Brand: Tocris Bioscience
SKU: 6526

Tocris Bioscience, part of Bio-Techne | Catalog # 6526

Citations (6)

COA / SDS

Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein

Key Product Details

Description:	Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
Chemical Name:	Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	431.5

View Full Technical Details for Dynarrestin

Technical Data
Citations

Biological Activity for Dynarrestin

Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC₅₀ = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Technical Data for Dynarrestin

M. Wt	431.5
Formula	C₂₂H₂₃F₂N₃O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2222768-84-3
PubChem ID	137919864
InChi Key	UZNNDDDSGCMQOQ-UHFFFAOYSA-N
Smiles	CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Dynarrestin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.15	100

Preparing Stock Solutions for Dynarrestin

The following data is based on the product molecular weight 431.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.17 mL
5 mM	0.46 mL	2.32 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Dynarrestin

References are publications that support the biological activity of the product.

Höing Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 2018 PMID: 29396292