Echinomycin

Name: Echinomycin
Brand: Tocris Bioscience
SKU: 5520

Tocris Bioscience, part of Bio-Techne | Catalog # 5520

Citations (13)

COA / SDS

Highly potent and selective HIF-1α inhibitor

Key Product Details

Description:	Highly potent and selective HIF-1α inhibitor
Alternative Names:	Quinomycin A
Chemical Name:	N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
Purity:	≥98% (HPLC)
Molecular Weight:	1101.26

View Full Technical Details for Echinomycin

Technical Data
Citations

Biological Activity for Echinomycin

Echinomycin is a highly potent and selective HIF-1α inhibitor (IC₅₀ = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

Technical Data for Echinomycin

M. Wt	1101.26
Formula	C₅₁H₆₄N₁₂O₁₂S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	512-64-1
PubChem ID	91826096
InChi Key	AUJXLBOHYWTPFV-LDUXBRJQSA-N
Smiles	O=C(N[C@](C(N[C@H](C(N(C)[C@@](C(SC[C@@](N(C)C([C@H](C)NC4=O)=O)([H])C3=O)SC)([H])C(N(C)[C@@H]([C@@H](C)C)C(OC[C@]([H])4NC(C5=CN=C(C=CC=C6)C6=N5)=O)=O)=O)=O)C)=O)([H])COC([C@H]([C@@H](C)C)N3C)=O)C2=NC1=CC=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Echinomycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5

Preparing Stock Solutions for Echinomycin

The following data is based on the product molecular weight 1101.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	18.16 mL	90.81 mL	181.61 mL
0.25 mM	3.63 mL	18.16 mL	36.32 mL
0.5 mM	1.82 mL	9.08 mL	18.16 mL
2.5 mM	0.36 mL	1.82 mL	3.63 mL

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References for Echinomycin

References are publications that support the biological activity of the product.

Kwon Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J.Cell.Biochem. 2011 PMID: 21793044
Kong Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 PMID: 16204079
Wang Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 2011 PMID: 21474104