EHop 016

Name: EHop 016
Brand: Tocris Bioscience
SKU: 6248

Tocris Bioscience, part of Bio-Techne | Catalog # 6248

Citations (8)

COA / SDS

Rac inhibitor

Key Product Details

Description:	Rac inhibitor
Chemical Name:	N⁴-(9-Ethyl-9H-carbazol-3-yl)-N²-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
Purity:	≥98% (HPLC)
Molecular Weight:	430.55

View Full Technical Details for EHop 016

Technical Data
Citations

Biological Activity for EHop 016

EHop 016 is a Rac inhibitor (IC₅₀ = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.

Compound Libraries for EHop 016

EHop 016 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EHop 016

M. Wt	430.55
Formula	C₂₅H₃₀N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1380432-32-5
PubChem ID	51031035
InChi Key	AFTZZRFCMOAFCR-UHFFFAOYSA-N
Smiles	CCN1C2=CC=C(NC3=NC(NCCCN4CCOCC4)=NC=C3)C=C2C5=CC=CC=C51

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EHop 016

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.53	50

Preparing Stock Solutions for EHop 016

The following data is based on the product molecular weight 430.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.65 mL	23.23 mL	46.45 mL
2.5 mM	0.93 mL	4.65 mL	9.29 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
25 mM	0.09 mL	0.46 mL	0.93 mL

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References for EHop 016

References are publications that support the biological activity of the product.

Montalvo-Ortiz Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J.Biol.Chem. 2012 PMID: 22383527
Castillo-Pichardo The Rac inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model. Transl.Oncol. 2014 PMID: 25389450