EHT 1864

Biological Activity for EHT 1864

Technical Data for EHT 1864

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EHT 1864

References for EHT 1864

References are publications that support the biological activity of the product.

• Kundumani-Sridharan, Venkates, Singh, Nikhlesh, Kumar, Sanjay, Gadepalli, Ravisekh, Rao, Gadipart Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall remodeling. J Biol Chem, 2013;288(30):22150-62. 2013 PMID: 23737530
• Yu M, Wang J, Muller D, Helenius J In PC3 prostate cancer cells ephrin receptors crosstalk to beta1-integrins to strengthen adhesion to collagen type I. Sci Rep, 2015;5(0):8206. 2015 PMID: 25644492
• Sidarala V, Veluthakal R, Syeda K, Kowluru A EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic beta-cells. Cell Signal, 2015;27(6):1159-67. 2015 PMID: 25725286
• Chang T, Kang H, Kim K, Lee S, Nam B, Paeng J, Kim S, Park J, Yoo T, Kang S, Han S The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells. PLoS ONE, 2014;9(10):e109628. 2014 PMID: 25275561
• CH Stuelten, RM Lee, W Losert, CA Parent Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways Cell. Signal., 2018;0(0):. 2018 PMID: 29337044
• Weidemann A, Breyer J, Rehm M, Eckardt K, Daniel C, Cicha I, Giehl K, Goppelt-Struebe M HIF-1alpha activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells. Cell Commun Signal, 2013;11(0):80. 2013 PMID: 24144209
• van Hooren K, van Breevoort D, Fernandez-Borja M, Meijer A, Eikenboom J, Bierings R, Voorberg J Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies. J Thromb Haemost, 2014;12(2):273-81. 2014 PMID: 24283667
• Carrim N, Walsh T, Consonni A, Torti M, Berndt M, Metharom P Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. PLoS ONE, 2014;9(11):e113679. 2014 PMID: 25415317
• Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H Endophilin marks and controls a clathrin-independent endocytic pathway. Nature, 2015;517(7535):460-5. 2015 PMID: 25517094
• Desire et al. RAC1 inhibition targets amyloid precursor protein processing by γ-secretase and decreases Aβ production in vitro and in vivo. J.Biol.Chem., 2005;280:37516 PMID: 16150730
• Shutes et al. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of rac family small GTPases. J.Biol.Chem., 2007;282:35666 PMID: 17932039
• Onesto et al. Characterization of EHT1864, a novel small molecule inhibitor of Rac family small GTPases. Methods Enzymol., 2008;439:111 PMID: 18374160