EMD 386088 hydrochloride

Name: EMD 386088 hydrochloride
Brand: Tocris Bioscience
SKU: 2382

Tocris Bioscience, part of Bio-Techne | Catalog # 2382

COA / SDS

Potent 5-HT6 agonist

Key Product Details

Description:	Potent 5-HT₆ agonist
Chemical Name:	5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	283.2

View Full Technical Details for EMD 386088 hydrochloride

Technical Data
Citations

Biological Activity for EMD 386088 hydrochloride

EMD 386088 hydrochloride is a potent 5-HT₆ receptor agonist (EC₅₀= 1.0 nM) that displays selectivity over other 5-HT receptors (IC₅₀ values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT₆, 5-HT_1D, 5-HT_1B, 5-HT_2A, 5-HT_2C, 5-HT₄, 5-HT_1A and 5-HT₇ receptors respectively). Shows moderate affinity at 5-HT₃ receptors (IC₅₀ = 34 nM).

Compound Libraries for EMD 386088 hydrochloride

EMD 386088 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EMD 386088 hydrochloride

M. Wt	283.2
Formula	C₁₄H₁₅N₂Cl.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1171123-46-8
PubChem ID	56972198
InChi Key	WWSNDUWIZDYGIQ-UHFFFAOYSA-N
Smiles	Cl.CC1=C(C2=CC(Cl)=CC=C2N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EMD 386088 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	7.08	25
	DMSO	28.32	100

Preparing Stock Solutions for EMD 386088 hydrochloride

The following data is based on the product molecular weight 283.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.66 mL	35.31 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.77 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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References for EMD 386088 hydrochloride

References are publications that support the biological activity of the product.

Mattsson 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT₆ receptor agonists. Bioorg.Med.Chem.Lett. 2005 PMID: 16055331