Emetine dihydrochloride

Name: Emetine dihydrochloride
Brand: Tocris Bioscience
SKU: 7342

Tocris Bioscience, part of Bio-Techne | Catalog # 7342

Citations (7)

COA / SDS

RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika

Key Product Details

Description:	RNA polymerase inhibitor; inhibits replication of a broad range of RNA and DNA viruses, including SARS-CoV-2 and Zika
Chemical Name:	(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	553.57

View Full Technical Details for Emetine dihydrochloride

Technical Data
Citations

Biological Activity for Emetine dihydrochloride

Emetine is a RNA polymerase inhibitor. It inhibits SARS-CoV-2 replication (EC₅₀ = 460 nM) and in combination with Remdesivir (Cat. No.7226) synergistically inhibits the viral yield of SARS-CoV-2 by 64.9%. Emetine attenuates hCoV-OC43, hCoV-NL43, SARS-CoV, MERS-CoV, and MHV-A59 in vitro with EC₅₀ values in the low micromolar range. It also inhibits replication of a broad range of RNA and DNA viruses, including influenza, ebolavirus and HIV-1. Emetine potently inhibits ZIKV replication in vitro (IC₅₀ = 52.9 nm) and suppresses ZIKV viral load in vivo. Anti-inflammatory, antiviral, antimalarial, antibacterial and anti-amebic.

Technical Data for Emetine dihydrochloride

M. Wt	553.57
Formula	C₂₉H₄₀N₂O₄.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	316-42-7
PubChem ID	3068143
InChi Key	JROGBPMEKVAPEH-GXGBFOEMSA-N
Smiles	[H][C@@]1(NCCC2=CC(OC)=C(C=C12)OC)C[C@H]3C[C@@]4(N(C[C@@H]3CC)CCC5=CC(OC)=C(C=C45)OC)[H].Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Emetine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	55.36	100

Preparing Stock Solutions for Emetine dihydrochloride

The following data is based on the product molecular weight 553.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.03 mL	18.06 mL
5 mM	0.36 mL	1.81 mL	3.61 mL
10 mM	0.18 mL	0.90 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for Emetine dihydrochloride

References are publications that support the biological activity of the product.

Killick Transcription-based drug repurposing for COVID-19. Virus Res. 2020 PMID: 32987033
Bleasel Emetine is not Ipecac: considerations for its use as treatment for SARS-CoV2. Pharmaceuticals (Basel) 2020 PMID: 33261173
Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 PMID: 32251767
Bleasel Emetine, ipecac, ipecac alkaloids and analogues as potential antiviral agents for coronaviruses. Pharmaceuticals (Basel) 2020 PMID: 32245264
Yang Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 2018 PMID: 29872540