Enoximone

Name: Enoximone
Brand: Tocris Bioscience
SKU: 1693

Tocris Bioscience, part of Bio-Techne | Catalog # 1693

Citations (3)

COA / SDS

PDE3 inhibitor

Key Product Details

Description:	PDE3 inhibitor
Chemical Name:	1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	248.3

View Full Technical Details for Enoximone

Technical Data
Citations

Biological Activity for Enoximone

Enoximone is an inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro.

Technical Data for Enoximone

M. Wt	248.3
Formula	C₁₂H₁₂N₂O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	77671-31-9
PubChem ID	53708
InChi Key	ZJKNESGOIKRXQY-UHFFFAOYSA-N
Smiles	CC(NC(N2)=O)=C2C(C1=CC=C(SC)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Enoximone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	24.83	100

Preparing Stock Solutions for Enoximone

The following data is based on the product molecular weight 248.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.14 mL	40.27 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
10 mM	0.40 mL	2.01 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References for Enoximone

References are publications that support the biological activity of the product.

Pacher and Stanek Ambulatory vasodilator therapy in heart failure: systematic review of the literature and personal observational experience. Eur.J.Heart Fail. 1999 PMID: 10935673
Vroom Effect of phosphodiesterase inhibitors on human arteries in vitro. Br.J.Anaesth. 1996 PMID: 8672353
Jung Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, o J.Pharmacol.Exp.Ther. 2005 PMID: 15550574