Eplerenone

Name: Eplerenone
Brand: Tocris Bioscience
SKU: 2397

Tocris Bioscience, part of Bio-Techne | Catalog # 2397

Citations (18)

COA / SDS

Selective mineralocorticoid receptor antagonist

Key Product Details

Description:	Selective mineralocorticoid receptor antagonist
Alternative Names:	Inspra,Epoxymexrenone
Chemical Name:	(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	414.5

View Full Technical Details for Eplerenone

Technical Data
Citations

Biological Activity for Eplerenone

Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC₅₀ = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC₅₀ > 10 μM). Orally active antihypertensive in vivo.

Technical Data for Eplerenone

M. Wt	414.5
Formula	C₂₄H₃₀O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	107724-20-9
PubChem ID	443872
InChi Key	JUKPWJGBANNWMW-VWBFHTRKSA-N
Smiles	O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Eplerenone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.14	10

Preparing Stock Solutions for Eplerenone

The following data is based on the product molecular weight 414.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.13 mL	120.63 mL	241.25 mL
0.5 mM	4.83 mL	24.13 mL	48.25 mL
1 mM	2.41 mL	12.06 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL

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Reconstitution Calculator

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References for Eplerenone

References are publications that support the biological activity of the product.

McMahon and Cunningham Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 2001 PMID: 11714095
De Gasparo Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 1987 PMID: 2949071