EPZ 015666

Name: EPZ 015666
Brand: Tocris Bioscience
SKU: 6516

Tocris Bioscience, part of Bio-Techne | Catalog # 6516

Citations (3)

COA / SDS

Potent and selective PRMT5 inhibitor

Key Product Details

Chemical Name:	N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
Purity:	≥98%

View Full Technical Details for EPZ 015666

Technical Data
Citations

Biological Activity for EPZ 015666

EPZ 015666 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC₅₀ = 22 nM, K_i = 5 nM). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases. Exhibits dose-dependent antitumor effects in multiple mantle cell lymphoma (MCL) xenograft models. Orally bioavailable.

Technical Data for EPZ 015666

Formula	C₂₀H₂₅N₅O₃
Storage	Store at -20°C
Purity	≥98%
CAS Number	1616391-65-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EPZ 015666

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for EPZ 015666

References are publications that support the biological activity of the product.

Duncan et al. Structure and property guided design in the identification of PRMT5 tool compound EPZ015666. ACS Med.Chem.Lett., 2015;7:162 PMID: 26985292
Chan-Penebre et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat.Chem.Biol., 2015;11:432 PMID: 25915199

EPZ 015666

Tocris Bioscience, part of Bio-Techne | Catalog # 6516

Key Product Details

Biological Activity for EPZ 015666

Technical Data for EPZ 015666

Solubility for EPZ 015666

Dilution Calculator

Reconstitution Calculator

References for EPZ 015666

Product Documents for EPZ 015666

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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