ER 50891

Name: ER 50891
Brand: Tocris Bioscience
SKU: 3823

Tocris Bioscience, part of Bio-Techne | Catalog # 3823

Citations (24)

COA / SDS

Selective RARα antagonist

Key Product Details

Description:	Selective RARα antagonist
Chemical Name:	4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	432.51

View Full Technical Details for ER 50891

Technical Data
Citations

Biological Activity for ER 50891

ER 50891 is an antagonist of RARα receptors (IC₅₀ = 31.2 nM). Displays selective affinity for RARα (relative IC₅₀ values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively).

Compound Libraries for ER 50891

ER 50891 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ER 50891

M. Wt	432.51
Formula	C₂₉H₂₄N₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	187400-85-7
PubChem ID	10094345
InChi Key	LSGNKLDHMQVTEK-UHFFFAOYSA-N
Smiles	CC(C)C1=C2C(C(C3=CC=CC=C3)=CC(C4=CC=C(C5=CC=C(C(O)=O)C=C5)N4)=N2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ER 50891

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.25	100

Preparing Stock Solutions for ER 50891

The following data is based on the product molecular weight 432.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.31 mL	11.56 mL	23.12 mL
5 mM	0.46 mL	2.31 mL	4.62 mL
10 mM	0.23 mL	1.16 mL	2.31 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for ER 50891

References are publications that support the biological activity of the product.

Ren Impaired retinoic acid (RA) signal leads to RARβ2 epigenetic silencing and RA resistance. Mol.Cell.Biol. 2005 PMID: 16287870
Somenzi Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. PLoS ONE 2007 PMID: 17786207
Kikuchi Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor α antagonists. Bioorg.Med.Chem.Lett. 2001 PMID: 11354380