Etifoxine hydrochloride

Name: Etifoxine hydrochloride
Brand: Tocris Bioscience
SKU: 3113

Tocris Bioscience, part of Bio-Techne | Catalog # 3113

Citations (1)

COA / SDS

Ligand of the translocator protein (TSPO); also GABAA receptor potentiator

Key Product Details

Description:	Ligand of the translocator protein (TSPO); also GABA_A receptor potentiator
Chemical Name:	6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	337.24

View Full Technical Details for Etifoxine hydrochloride

Technical Data
Citations

Biological Activity for Etifoxine hydrochloride

Etifoxine hydrochloride is a potentiator of GABA_A receptor function in cultured neurons. Preferentially acts on β₂ or β₃ subunit-containing GABA_A receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.

Compound Libraries for Etifoxine hydrochloride

Etifoxine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Etifoxine hydrochloride

M. Wt	337.24
Formula	C₁₇H₁₇ClN₂O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	56776-32-0
PubChem ID	171544
InChi Key	SCBJXEBIMVRTJE-UHFFFAOYSA-N
Smiles	CCNC2=NC1=CC=C(Cl)C=C1C(C3=CC=CC=C3)(C)O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Etifoxine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.72	100

Preparing Stock Solutions for Etifoxine hydrochloride

The following data is based on the product molecular weight 337.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.83 mL	29.65 mL
5 mM	0.59 mL	2.97 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for Etifoxine hydrochloride

References are publications that support the biological activity of the product.

Girard Etifoxine improves peripheral nerve regeneration and functional recovery. Proc.Natl.Acad.Sci. 2008 PMID: 19075249
Hamon The modulatory effects of the anxiolytic etifoxine on GABA_A receptors are mediated by the β subunit. Neuropharmacology 2003 PMID: 12871647