EXP 3174

Name: EXP 3174
Brand: Tocris Bioscience
SKU: 5728

Tocris Bioscience, part of Bio-Techne | Catalog # 5728

COA / SDS

Potent and selective AT1 antagonist

Key Product Details

Description:	Potent and selective AT₁ antagonist
Chemical Name:	2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	436.89

View Full Technical Details for EXP 3174

Technical Data
Citations

Biological Activity for EXP 3174

EXP 3174 is a potent and selective noncompetitive AT₁ receptor antagonist (IC₅₀ = 37 nM). Reduces blood pressure in a rat model. Active metabolite of Losartan potassium (Cat. No. 3798).

Compound Libraries for EXP 3174

EXP 3174 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for EXP 3174

M. Wt	436.89
Formula	C₂₂H₂₁ClN₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	124750-92-1
PubChem ID	108185
InChi Key	ZEUXAIYYDDCIRX-UHFFFAOYSA-N
Smiles	CCCCC1=NC(Cl)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EXP 3174

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.69	100
	ethanol	43.69	100

Preparing Stock Solutions for EXP 3174

The following data is based on the product molecular weight 436.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.14 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for EXP 3174

References are publications that support the biological activity of the product.

Wong Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 1990 PMID: 2213556