Fasentin

Name: Fasentin
Brand: Tocris Bioscience
SKU: 6100

Tocris Bioscience, part of Bio-Techne | Catalog # 6100

Citations (4)

COA / SDS

GLUT1/GLUT4 inhibitor; also Fas-sensitizer

Key Product Details

Description:	GLUT1/GLUT4 inhibitor; also Fas-sensitizer
Chemical Name:	N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Purity:	≥98% (HPLC)
Molecular Weight:	279.64

View Full Technical Details for Fasentin

Technical Data
Citations

Biological Activity for Fasentin

Fasentin is a GLUT1 and GLUT4 inhibitor (IC₅₀ = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC₅₀ = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.

Technical Data for Fasentin

M. Wt	279.64
Formula	C₁₁H₉ClF₃NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	392721-37-8
PubChem ID	879520
InChi Key	GNYIJZMBLZXJEJ-UHFFFAOYSA-N
Smiles	CC(CC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fasentin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.96	100
	ethanol	27.96	100

Preparing Stock Solutions for Fasentin

The following data is based on the product molecular weight 279.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.58 mL	17.88 mL	35.76 mL
5 mM	0.72 mL	3.58 mL	7.15 mL
10 mM	0.36 mL	1.79 mL	3.58 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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Reconstitution Calculator

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References for Fasentin

References are publications that support the biological activity of the product.

Wood A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 2008 PMID: 19001437
Granchi Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 2016 PMID: 28042452
Schimmer Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 2006 PMID: 16489043