Fatostatin A

Name: Fatostatin A
Brand: Tocris Bioscience
SKU: 4444

Tocris Bioscience, part of Bio-Techne | Catalog # 4444

Citations (12)

COA / SDS

Cell permeable inhibitor of SREBP activation

Key Product Details

Description:	Cell permeable inhibitor of SREBP activation
Chemical Name:	4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
Purity:	≥97% (HPLC)
Molecular Weight:	375.33

View Full Technical Details for Fatostatin A

Technical Data
Citations

Biological Activity for Fatostatin A

Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC₅₀ = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.

Compound Libraries for Fatostatin A

Fatostatin A is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Fatostatin A

M. Wt	375.33
Formula	C₁₈H₁₈N₂S.HBr
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	298197-04-3
PubChem ID	2850562
InChi Key	RJCFNQZVFUMORB-UHFFFAOYSA-N
Smiles	CCCC1=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=CC=N1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fatostatin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.51	20

Preparing Stock Solutions for Fatostatin A

The following data is based on the product molecular weight 375.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.32 mL	66.61 mL	133.22 mL
1 mM	2.66 mL	13.32 mL	26.64 mL
2 mM	1.33 mL	6.66 mL	13.32 mL
10 mM	0.27 mL	1.33 mL	2.66 mL

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References for Fatostatin A

References are publications that support the biological activity of the product.

Choi Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 2003 PMID: 12496288
Kamisuki A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 2009 PMID: 19716478