Favipiravir

Name: Favipiravir
Brand: Tocris Bioscience
SKU: 7225

Tocris Bioscience, part of Bio-Techne | Catalog # 7225

Citations (1)

COA / SDS

Viral RNA polymerase inhibitor

Key Product Details

Description:	Viral RNA polymerase inhibitor
Alternative Names:	T 705
Chemical Name:	6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	157.1

View Full Technical Details for Favipiravir

Technical Data
Citations

Biological Activity for Favipiravir

Favipiravir is a viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 cells in vitro (IC₅₀ = 61.88 μM). Inhibits influenza virus RNA-dependent RNA polymerase (RdRP) activity (IC₅₀ = 341 nM). Induces lethal mutagenesis in MDCK cells inoculated with seasonal influenza A (H1N1) viruses. Protects mice against Ebola virus.

Compound Libraries for Favipiravir

Favipiravir is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Favipiravir

M. Wt	157.1
Formula	C₅H₄FN₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	259793-96-9
PubChem ID	492405
InChi Key	ZCGNOVWYSGBHAU-UHFFFAOYSA-N
Smiles	NC(C1=NC(F)=CNC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Favipiravir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.71	100
	ethanol	3.14	20

Preparing Stock Solutions for Favipiravir

The following data is based on the product molecular weight 157.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.37 mL	31.83 mL	63.65 mL
5 mM	1.27 mL	6.37 mL	12.73 mL
10 mM	0.64 mL	3.18 mL	6.37 mL
50 mM	0.13 mL	0.64 mL	1.27 mL

Molarity Calculator

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Reconstitution Calculator

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References for Favipiravir

References are publications that support the biological activity of the product.

Furuta In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob.Agents Chemother. 2002 PMID: 11897578
Wang Remdesivir and Chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 PMID: 32020029