FC 11

Name: FC 11
Brand: Tocris Bioscience
SKU: 7306

Tocris Bioscience, part of Bio-Techne | Catalog # 7306

COA / SDS

Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)

Key Product Details

Description:	Highly potent focal adhesion kinase (FAK) Degrader (PROTAC^®)
Chemical Name:	1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	949.92

View Full Technical Details for FC 11

Technical Data
Citations

Biological Activity for FC 11

FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC^® Degrader (DC₅₀ values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAK^tyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

FAK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4467 and MAB4467.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for FC 11

M. Wt	949.92
Formula	C₄₁H₄₂F₃N₁₃O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2271035-37-9
PubChem ID	154723926
InChi Key	RZKZQCHSKWKOAJ-UHFFFAOYSA-N
Smiles	CN(S(C)(=O)=O)C1=C(C=CC=N1)CNC2=NC(NC3=CC=C(C=C3)NC(C4=CN(N=N4)CCOCCOCCNC5=C6C(N(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O)=O)=NC=C2C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FC 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	94.99	100

Preparing Stock Solutions for FC 11

The following data is based on the product molecular weight 949.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.05 mL	5.26 mL	10.53 mL
5 mM	0.21 mL	1.05 mL	2.11 mL
10 mM	0.11 mL	0.53 mL	1.05 mL
50 mM	0.02 mL	0.11 mL	0.21 mL

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References for FC 11

References are publications that support the biological activity of the product.

Gao Design, synthesis, and evaluation of highly potent FAK-targeting PROTACs. ACS.Med.Chem.Lett. 2019 PMID: 33062164