FCCP

Name: FCCP
Brand: Tocris Bioscience
SKU: 0453
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0453

(2)

Citations (82)

COA / SDS

Oxidative phosphorylation uncoupler

Key Product Details

Description:	Oxidative phosphorylation uncoupler
Chemical Name:	Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Purity:	≥99% (HPLC)
Molecular Weight:	254.17

View Full Technical Details for FCCP

Technical Data
Citations / Reviews (2)

Biological Activity for FCCP

FCCP is a very potent uncoupler of oxidative phosphorylation in mitochondria.

Technical Data for FCCP

M. Wt	254.17
Formula	C₁₀H₅F₃N₄O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	370-86-5
PubChem ID	3330
InChi Key	BMZRVOVNUMQTIN-UHFFFAOYSA-N
Smiles	N#CC(C#N)=NNC1=CC=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FCCP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.42	100

Preparing Stock Solutions for FCCP

The following data is based on the product molecular weight 254.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.67 mL	39.34 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for FCCP

References are publications that support the biological activity of the product.

Heytler and Pritchard A new class of uncoupling agents - carbonyl cyanide phenylhydrazones. Biochem.Biophys.Res.Commun. 1962 PMID: 13907155
Connop Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J.Neurochem. 1999 PMID: 10098849