Fexaramine

Name: Fexaramine
Brand: Tocris Bioscience
SKU: 2563

Tocris Bioscience, part of Bio-Techne | Catalog # 2563

Citations (4)

COA / SDS

Potent, selective farnesoid X receptor (FXR) agonist

Key Product Details

Description:	Potent, selective farnesoid X receptor (FXR) agonist
Chemical Name:	3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester
Purity:	≥97% (HPLC)
Molecular Weight:	496.64

View Full Technical Details for Fexaramine

Technical Data
Citations

Biological Activity for Fexaramine

Fexaramine is a potent, selective farnesoid X receptor agonist (EC₅₀ = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Compound Libraries for Fexaramine

Fexaramine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Fexaramine

M. Wt	496.64
Formula	C₃₂H₃₆N₂O₃
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	574013-66-4
PubChem ID	5326713
InChi Key	VLQTUNDJHLEFEQ-KGENOOAVSA-N
Smiles	O=C(C3CCCCC3)N(CC2=CC=C(C4=CC=C(N(C)C)C=C4)C=C2)C1=CC(/C=C/C(OC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fexaramine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.66	100

Preparing Stock Solutions for Fexaramine

The following data is based on the product molecular weight 496.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.07 mL	20.14 mL
5 mM	0.40 mL	2.01 mL	4.03 mL
10 mM	0.20 mL	1.01 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Fexaramine

References are publications that support the biological activity of the product.

Downes A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 2003 PMID: 12718892
Pellicciari Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 2006 PMID: 16821780
Nicolaou Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 2003 PMID: 12929628