FIN 56

Name: FIN 56
Brand: Tocris Bioscience
SKU: 6280

Tocris Bioscience, part of Bio-Techne | Catalog # 6280

Citations (2)

COA / SDS

Ferroptosis activator

Key Product Details

Description:	Ferroptosis activator
Chemical Name:	N²,N⁷-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	517.66

View Full Technical Details for FIN 56

Technical Data
Citations

Biological Activity for FIN 56

FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q₁₀ depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).

Compound Libraries for FIN 56

FIN 56 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FIN 56

M. Wt	517.66
Formula	C₂₅H₃₁N₃O₅S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1083162-61-1
PubChem ID	118986699
InChi Key	JLCFMMIWBSZOIS-UHFFFAOYSA-N
Smiles	ON=C1C2=CC(=CC=C2C2=CC=C(C=C12)S(=O)(=O)NC1CCCCC1)S(=O)(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FIN 56

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.77	100

Preparing Stock Solutions for FIN 56

The following data is based on the product molecular weight 517.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.66 mL	19.32 mL
5 mM	0.39 mL	1.93 mL	3.86 mL
10 mM	0.19 mL	0.97 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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Reconstitution Calculator

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References for FIN 56

References are publications that support the biological activity of the product.

Cotto-Rios and Gavathiotis Chemical genetics: Unraveling cell death mysteries. Nat.Chem.Biol. 2016 PMID: 27315536
Shimada Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat.Chem.Biol. 2016 PMID: 27159577