FK 888

Tocris Bioscience, part of Bio-Techne | Catalog # 2400

COA / SDS

High affinity NK1 antagonist

Key Product Details

Chemical Name:	(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
Purity:	≥98%
Molecular Weight:	588.69 kDa

View Full Technical Details for FK 888

Technical Data
Citations

Biological Activity for FK 888

FK 888 is a selective, high affinity tachykinin NK₁ receptor antagonist (K_i = 0.69 nM) that displays 320-fold selectivity for human over rat NK₁ receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC₅₀ = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.

Technical Data for FK 888

M. Wt	588.69 kDa
Formula	C₃₆H₃₆N₄O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	138449-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FK 888

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for FK 888

References are publications that support the biological activity of the product.

Fujii et al. Pharmacological profile of a high affinity dipeptide NK₁ receptor antagonist. Br.J.Pharmacol., 1992;107:785 PMID: 1282073
Murai et al. Effects of an NK₁ receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin. Eur.J.Pharmacol., 1993;236:7 PMID: 7686493
Aramori et al. Subtype- and species-selectivity of a tachykinin receptor antagonist, FK888, for cloned rat and human tachykinin receptors. Eur.J.Pharmacol., 1994;269:277 PMID: 7531648