Flecainide acetate

Name: Flecainide acetate
Brand: Tocris Bioscience
SKU: 1470

Tocris Bioscience, part of Bio-Techne | Catalog # 1470

Citations (3)

COA / SDS

Cardiac Na+ channel blocker. Antiarrhythmic

Key Product Details

Description:	Cardiac Na⁺ channel blocker. Antiarrhythmic
Chemical Name:	N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate
Purity:	≥99% (HPLC)
Molecular Weight:	474.4

View Full Technical Details for Flecainide acetate

Technical Data
Citations

Biological Activity for Flecainide acetate

Flecainide acetate is an open Na⁺ channel blocker that inhibits fast Na⁺ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

Compound Libraries for Flecainide acetate

Flecainide acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Flecainide acetate

M. Wt	474.4
Formula	C₁₇H₂₀F₆N₂O₃.C₂H₄O₂
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	54143-56-5
PubChem ID	41022
InChi Key	RKXNZRPQSOPPRN-UHFFFAOYSA-N
Smiles	CC(O)=O.FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C(=O)NCC1CCCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flecainide acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.86	25
	DMSO	47.44	100

Preparing Stock Solutions for Flecainide acetate

The following data is based on the product molecular weight 474.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for Flecainide acetate

References are publications that support the biological activity of the product.

Rouet and Ducouret Use-and concentration-dependent effects of fleca. in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 1994 PMID: 7526048
Singh The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 1984 PMID: 6395762
Banitt Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 1977 PMID: 874956