Fluorobexarotene

Name: Fluorobexarotene
Brand: Tocris Bioscience
SKU: 4064

Tocris Bioscience, part of Bio-Techne | Catalog # 4064

COA / SDS

RXR agonist

Discontinued Product

4064 has been discontinued. View all Retinoid X Receptor Agonists products.

Key Product Details

Description:	RXR agonist
Chemical Name:	2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	366.47

View Full Technical Details for Fluorobexarotene

Technical Data
Citations

Biological Activity for Fluorobexarotene

Fluorobexarotene is a RXR agonist (K_i = 12 nM; EC₅₀ = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.

Licensing Information

Manufactured and sold under license from Arizona State University - Patent Pending

Technical Data for Fluorobexarotene

M. Wt	366.47
Formula	C₂₄H₂₇FO₂
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	1190848-23-7
PubChem ID	25195496
InChi Key	LWKAWHRSPCHMPJ-UHFFFAOYSA-N
Smiles	CC(C(C(C3=CC=C(C(O)=O)C(F)=C3)=C)=C2)=CC1=C2C(C)(C)CCC(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Fluorobexarotene

References are publications that support the biological activity of the product.

Wagner Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 2009 PMID: 19791803