Flupirtine maleate

Name: Flupirtine maleate
Brand: Tocris Bioscience
SKU: 2867
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2867

(2)

Citations (5)

COA / SDS

KV7 channel activator; also GABAA modulator and indirect NMDA antagonist

Key Product Details

Description:	K_V7 channel activator; also GABA_A modulator and indirect NMDA antagonist
Alternative Names:	D 9998
Chemical Name:	N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Purity:	≥98% (HPLC)
Molecular Weight:	420.4

View Full Technical Details for Flupirtine maleate

Technical Data
Citations / Reviews (2)

Biological Activity for Flupirtine maleate

Flupirtine maleate is a non-opioid analgesic with muscle relaxant properties. Activates K_V7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABA_A receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Compound Libraries for Flupirtine maleate

Flupirtine maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Flupirtine maleate

M. Wt	420.4
Formula	C₁₅H₁₇FN₄O₂.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	75507-68-5
PubChem ID	53276
InChi Key	JUUFBMODXQKSTD-UHFFFAOYSA-N
Smiles	OC(=O)\C=C/C(O)=O.NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(F)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flupirtine maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.04	100
	ethanol	4.2	10

Preparing Stock Solutions for Flupirtine maleate

The following data is based on the product molecular weight 420.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.89 mL	23.79 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Flupirtine maleate

References are publications that support the biological activity of the product.

Klinger Concomitant facilitation of GABA_A receptors and K_V7 channels by the non-opioid analgesic flupirtine. Br.J.Pharmacol. 2012 PMID: 22188423
Azad The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice. Neurosci.Lett. 2004 PMID: 15488320
Yeung Molecular expression and pharmacological identification of a role for K_v7 channels in murine vascular reactivity. Br.J.Pharmacol. 2007 PMID: 17519950
Osborne Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen.Pharmacol. 1998 PMID: 9510072