Flupirtine maleate

Name: Flupirtine maleate
Brand: Tocris Bioscience
SKU: 2867

Tocris Bioscience, part of Bio-Techne | Catalog # 2867

(2)

Citations (5)

COA / SDS

KV7 channel activator; also GABAA modulator and indirect NMDA antagonist

Key Product Details

Chemical Name:	N-[2-Amino-6-[[4-fluorophenyl)methyl]amino]-3-pyridinyl]carbamic acid ethyl ester maleate
Purity:	≥98%
Molecular Weight:	420.4 kDa

View Full Technical Details for Flupirtine maleate

Technical Data
Citations / Reviews (2)

Biological Activity for Flupirtine maleate

Flupirtine maleate is a non-opioid analgesic with muscle relaxant properties. Activates K_V7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABA_A receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

Technical Data for Flupirtine maleate

M. Wt	420.4 kDa
Formula	C₁₅H₁₇FN₄O₂.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥98%
CAS Number	75507-68-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flupirtine maleate

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for Flupirtine maleate

References are publications that support the biological activity of the product.

Klinger Concomitant facilitation of GABA_A receptors and K_V7 channels by the non-opioid analgesic flupirtine. Br.J.Pharmacol., 2012;166:1631 PMID: 22188423
Osborne et al. Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen.Pharmacol., 1998;30:255 PMID: 9510072
Azad et al. The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice. Neurosci.Lett., 2004;370:186 PMID: 15488320
Yeung et al. Molecular expression and pharmacological identification of a role for K_v7 channels in murine vascular reactivity. Br.J.Pharmacol., 2007;151:758 PMID: 17519950