Flutamide

Name: Flutamide
Brand: Tocris Bioscience
SKU: 4094

Tocris Bioscience, part of Bio-Techne | Catalog # 4094

Citations (20)

COA / SDS

Non-steroidal androgen receptor antagonist

Key Product Details

Description:	Non-steroidal androgen receptor antagonist
Alternative Names:	SCH 13521
Chemical Name:	2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
Purity:	≥98% (HPLC)
Molecular Weight:	276.21

View Full Technical Details for Flutamide

Technical Data
Citations

Biological Activity for Flutamide

Flutamide is a non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone in vivo.

Compound Libraries for Flutamide

Flutamide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Flutamide

M. Wt	276.21
Formula	C₁₁H₁₁F₃N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	13311-84-7
PubChem ID	3397
InChi Key	MKXKFYHWDHIYRV-UHFFFAOYSA-N
Smiles	CC(C)C(NC1=CC(C(F)(F)F)=C([N+]([O-])=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flutamide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.62	100
	ethanol	27.62	100

Preparing Stock Solutions for Flutamide

The following data is based on the product molecular weight 276.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.10 mL	36.20 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

Molarity Calculator

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Reconstitution Calculator

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References for Flutamide

References are publications that support the biological activity of the product.

Butcher Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 2007 PMID: 17210686
Foster Drug safety is a barrier to the discovery and development of new androgen receptor antagonists. Prostate 2011 PMID: 20878947
Sufrin and Coffey Flutamide. Mechanism of action of a new nonsteroidal antiandrogen. Invest.Urol. 1976 PMID: 1270239

Product Documents for Flutamide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Flutamide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov