Fluticasone propionate

Name: Fluticasone propionate
Brand: Tocris Bioscience
SKU: 2007

Tocris Bioscience, part of Bio-Techne | Catalog # 2007

Citations (414)

COA / SDS

Selective high affinity glucocorticoid receptor agonist

Key Product Details

Description:	Selective high affinity glucocorticoid receptor agonist
Chemical Name:	(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	500.57

View Full Technical Details for Fluticasone propionate

Technical Data
Citations

Biological Activity for Fluticasone propionate

Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (K_d = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC₅₀ = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates K_V1 channels (EC₅₀ = 37 nM).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for Fluticasone propionate

Fluticasone propionate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fluticasone propionate

M. Wt	500.57
Formula	C₂₅H₃₁F₃O₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	80474-14-2
PubChem ID	444036
InChi Key	WMWTYOKRWGGJOA-CENSZEJFSA-N
Smiles	O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fluticasone propionate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.03	50

Preparing Stock Solutions for Fluticasone propionate

The following data is based on the product molecular weight 500.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.00 mL	19.98 mL	39.95 mL
2.5 mM	0.80 mL	4.00 mL	7.99 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
25 mM	0.08 mL	0.40 mL	0.80 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Fluticasone propionate

References are publications that support the biological activity of the product.

Pan Potentiation of the Kv1 family K⁺ channel by cortisone analogues. ACS Chem.Biol. 2012 PMID: 22803826
Zhang Enhancement of human eosinophil apoptosis by flutic. propionate, budesonide, and beclometh. Eur.J.Pharmacol. 2000 PMID: 11040338
Smith and Kreutner In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneim.-Forsch.
Johnson The anti-inflammatory profile of flutic. propionate. Allergy 1995 PMID: 7604948

Product Documents for Fluticasone propionate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Fluticasone propionate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov