FMK 9a

Name: FMK 9a
Brand: Tocris Bioscience
SKU: 7496

Tocris Bioscience, part of Bio-Techne | Catalog # 7496

COA / SDS

Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B

Key Product Details

Description:	Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B
Chemical Name:	N-[(1S)-2-[(3-Fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-1-naphthalenecarboxamide
Purity:	≥90% (HPLC)
Molecular Weight:	392.43

View Full Technical Details for FMK 9a

Technical Data
Citations

Biological Activity for FMK 9a

FMK 9a is a potent ATG4B/autophagin-1 inhibitor (IC₅₀ values are 73 nM and 80 nM in cell-based LRA and TR-FRET assays, respectively). Also inhibits calpain and cathepsin B (IC₅₀ values are 96 nM and 200 nM, respectively).

Technical Data for FMK 9a

M. Wt	392.43
Formula	C₂₃H₂₁FN₂O₃
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	1955550-51-2
PubChem ID	127020966
InChi Key	VMVOHHPQIAPYHG-NRFANRHFSA-N
Smiles	FCC(CNC([C@@H](NC(C1=CC=CC2=C1C=CC=C2)=O)CC3=CC=CC=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FMK 9a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.24	100

Preparing Stock Solutions for FMK 9a

The following data is based on the product molecular weight 392.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for FMK 9a

References are publications that support the biological activity of the product.

Qiu Discovery of fluoromethylketone-based peptidomimetics as covalent ATG4B (autophagin-1) inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27563406