FR 122047 hydrochloride

Name: FR 122047 hydrochloride
Brand: Tocris Bioscience
SKU: 1507

Tocris Bioscience, part of Bio-Techne | Catalog # 1507

Citations (1)

COA / SDS

Cyclooxygenase (COX-1) inhibitor

Key Product Details

Description:	Cyclooxygenase (COX-1) inhibitor
Chemical Name:	1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	459.99

View Full Technical Details for FR 122047 hydrochloride

Technical Data
Citations

Biological Activity for FR 122047 hydrochloride

FR 122047 hydrochloride is a selective cyclooxygenase-1 (COX-1) inhibitor (IC₅₀ values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.

Technical Data for FR 122047 hydrochloride

M. Wt	459.99
Formula	C₂₃H₂₅N₃O₃S.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	130717-51-0
PubChem ID	196840
InChi Key	YWMAVHIKOAOSFM-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(C=C1)C1=C(N=C(S1)C(=O)N1CCN(C)CC1)C1=CC=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FR 122047 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	4.6	10

Preparing Stock Solutions for FR 122047 hydrochloride

The following data is based on the product molecular weight 459.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.74 mL	108.70 mL	217.40 mL
0.5 mM	4.35 mL	21.74 mL	43.48 mL
1 mM	2.17 mL	10.87 mL	21.74 mL
5 mM	0.43 mL	2.17 mL	4.35 mL

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References for FR 122047 hydrochloride

References are publications that support the biological activity of the product.

Tanaka Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. J.Med.Chem. 1994 PMID: 8164261
Ochi The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models. Eur.J.Pharmacol. 2000 PMID: 10720634
Ochi and Goto Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br.J.Pharmacol. 2002 PMID: 11834626
Dohi The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur.J.Pharmacol. 1993 PMID: 8276067